Nvalt review trial#
In the 1990s, much interest was generated from two small trials that reported striking results with neo-adjuvant chemotherapy, and therefore our intergroup randomised trial was designed to investigate whether, in patients with operable non-small cell lung cancer of any stage, outcomes could be improved by giving platinum-based chemotherapy before surgery.Methods Patients were randomised to receive either surgery alone (S), or three cycles of platinum-based chemotherapy followed by surgery (CT-S). Interpretation Although there was no evidence of a difference in overall survival with neo-adjuvant chemotherapy, the result is statistically consistent with previous trials, and therefore adds considerable weight to the current evidence.Ībstract = "Background Although surgery offers the best chance of cure for patients with non-small cell lung cancer (NSCLC), the overall 5-year survival rate is modest, and improvements are urgently needed. Updating the systematic review by addition of the present result suggests a 12% relative survival benefit with the addition of neoadjuvant chemotherapy (1507 patients, HR 0.88, 95% CI 0.76-1.01, p=0.07), equivalent to an absolute improvement in survival of 5% at 5 years However, there was no evidence of a benefit in terms of overall survival (hazard ratio 1.02, 95% Cl 0.80-1.31, p=0.86).
Post-operative complications were not increased in the CT-S group, and no impairment of quality of life was observed. Neo-adjuvant chemotherapy was feasible (75% of patients received all three cycles of chemotherapy), resulted in a good response rate (49% ) and down-staging in 31% (25%-37%) of patients, and did not alter the type or completeness of the surgery (lobectomy: S: 56%, CT-S: 60%, complete resection: S: 80%, CT-S: 82%). Most (61%) were clinical stage I, with 31% stage II, and 7% stage III. Results 519 patients were randomised (S: 261, CT-S: 258) from 70 centres in the UK, Netherlands, Germany, and Belgium. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN25582437. The primary outcome measure was overall survival, which was analysed on an intention-to-treat basis. Before randomisation, clinicians chose the chemotherapy that would be given from a list of six standard regimens. Methods Patients were randomised to receive either surgery alone (S), or three cycles of platinum-based chemotherapy followed by surgery (CT-S). In the 1990s, much interest was generated from two small trials that reported striking results with neo-adjuvant chemotherapy, and therefore our intergroup randomised trial was designed to investigate whether, in patients with operable non-small cell lung cancer of any stage, outcomes could be improved by giving platinum-based chemotherapy before surgery. I know how fast my thoughts can leave my mind and Drafts lets me capture faster on my iPad Air 2.Background Although surgery offers the best chance of cure for patients with non-small cell lung cancer (NSCLC), the overall 5-year survival rate is modest, and improvements are urgently needed.
Sometimes you want to capture something quickly. I’ve noticed that Drafts opens faster on my iPad Air 2. I’m excited to see Drafts 5 coming to the Mac. If you use it a lot, you can also learn the TaskPaper syntax and it will add the tags, due, defer, etc. It’s a nice way to keep templates outside of OmniFocus. In Drafts, you can have pre-designed project templates and send it over to OmniFocus. you don’t stop to use your mouse or tap on the iPad.
The beauty of using nvALT or Drafts is to rapid fire type away a bunch of actions quickly. Then boom, like magic, it appears in OmniFocus… I can choose to put it inside a folder or inside an existing project. I installed a Taskpaper to OF action in Drafts 5. Hit the Drafts button icon at the top right ( the square outline under the battery icon). The next few lines are indented and will be the tasks inside the project. Here’s an example of what I typed into Drafts 5: Sometimes it’s easier to go to Drafts 5 and rapid fire a bunch of tasks. If I wanted to quickly enter a bunch of tasks in OmniFocus 3 on my iPad, I would have to go to OmniFocus and create a new task, hit the Save + button and keep adding new tasks. I’ve never used nvALT but I imagine the same thing happens in Drafts 5.
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